Gudelines on management of palmoplantar keratoderma. Sep 27, 2016 keratoderma climactericum is a type of acquired palmoplantar keratoderma. Rarer forms of hereditary palmoplantar keratoderma are listed in appendix a. Acquired palmoplantar keratoderma associated with hypothyroidism. Pdf acquired palmoplantar keratoderma researchgate. Palmoplantar keratodermas ppk comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Differentiation between acquired and hereditary forms is essential for adequate treatment and patient counseling. While palmoplantar keratoderma is in most cases a genetic condition, there are situations in which it can be acquired, usually as a symptom of some inflammatory skin condition, such as psoriasis, eczema, ichthyosis, scabies, or dermatitis. Acquired palmoplantar keratoderma is more likely to present in adulthood compared with inherited keratodermas which usually present in childhood. Traditionally they have been classified as either hereditary or acquired and are distinguished from each other on the basis of mode of inheritance, presence of transgrediens defined as contiguous extension of hyperkeratosis beyond the palmar and.
They can also be acquired, such as manifestations of several diseases table. Although very rare, xanthogranulomatous pyelonephritis should be considered in the differential diagnosis of palmoplantar keratoderma. Ppk can be either acquired during the lifetime more commonly or inherited. Pdf the ridged skin of the palms and soles has several unique features. Acquired ppk may arise due to changes in a persons health or environment. Inherited forms of ppk are caused by genetic mutations that result in abnormalities of keratin a skin protein. Palmoplantar keratoderma is the name given to a group of conditions where there is abnormal thickening of the skin on the palms of the hands and soles of the feet. Keratoderma is a term that means marked thickening of the skin.
Acquired palmoplantar keratoderma pdf palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Palmoplantar keratodermas ppks comprise of a rare heterogeneous group of genetic and acquired keratinization disorders characterized by hyperkeratotic. Palmoplantar keratoderma medigoo health medical tests and. Ppk can be characterized as either inherited or acquired. Apr 16, 2019 palmoplantar keratoderma ppk constitutes a heterogeneous group of disorders characterized by thickening of the palms and the soles of individuals who are affected. Tr eatment of palmoplantar keratoderma with continuous. Acquired diffuse palmoplantar keratoderma breast lung gastric cancers leukemia lymphomas. Palmoplantar keratoderma is a thickening of the soles of feet and the palms of the hands. The 3 patients described possess a striking similarity to those with transient reactive papulotranslucent acrokeratoderma. The diagnosis, treatment, and prognosis of palmoplantar keratoderma.
Palmoplantar keratoderma is an ailment that involves a rather persistent thickening of the stratum corneum of the palms and soles. The various forms of ppk can be divided into hereditary forms with only skin problems, hereditary syndromes with ppk as an associated feature, and acquired forms. How to diagnose and manage hereditary palmoplantar. Aquagenic palmoplantar keratoderma is an acquired condition characterized by burning and edema limited to the hands after brief immersion in water. Congenital palmoplantar keratoderma, which is caused by genetic abnormalities that may be inherited in an autosomal dominant or recessive manner. Oral retinoid a vitamin a derivative and topical application of petrolatum salicylate or moisturizer are the main treatments. In a large family with epidermolytic palmoplantar keratoderma, reis et al. Our database lists the following as having palmoplantar keratoderma as a symptom of that condition. Palmoplantar keratodermas are a group of various inherited or acquired afflictions whose common denominator is the thickening of the skin of palms and soles. Palmoplantar keratoderma genetic and rare diseases. Current concepts in diagnosing and treating keratoderma. Paraneoplastic palmoplantar keratoderma ppk is an acquired dermatosis that presents with hyperkeratosis of the palms and soles in association with visceral malignancies eg, esophageal, gastric, pulmonary, and urinarybladder carcinomas. Palmoplantar keratoderma definition of palmoplantar.
It is characterized by thickening of the palms and the soles of individuals who are affected. In recent years, speculation has arisen that a molecular genetic classification system will replace the traditional, clinically based, descriptive systems. Schopfschulzpassarage syndrome is a rare ectodermal dysplasia characterized by hypodontia, hypotrichosis, nail dystrophy, palmoplantar keratoderma, and periocular and eyelid margin hidrocystomas. Ppk may be divided into acquired 2 and genetic types 3. Sep 10, 2012 palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Punctate palmoplantar keratoderma type i genetic and rare. Epidermolytic palmoplantar keratoderma vorner type case report. May 30, 2015 punctate keratoderma this ladys daughter had exactly the same lesions. Palmoplantar keratoderma is classified based on whether it is inherited or acquired and on its clinical features. Acquired ichthyosis acrokeratosis paraneoplastica extramammary pagets disease pityriasis rotunda florid cutaneous papillomatosis acquired diffuse palmoplantar keratoderma sign of lesertrelat tripe palms. Palmoplantar refers to the skin on the soles of the feet and palms of the hands. Palmoplantar keratoderma secondary to uterine cancer is rare.
His father also had this skin disorder, which coincidentally cleared after 2 courses of chemotherapy consisting of 5fu and cisplatin to treat his lung cancer, prompting the patient to undergo this trial of therapy. Palmoplantar keratodermas foundation for ichthyosis. The family of palmoplantar keratodermas are relatively uncommon diseases. Palmoplantar keratoderma genetic and rare diseases information.
Over 10 million scientific documents at your fingertips. The condition may be subdivided into hereditary keratodermas, acquired forms, and conditions in which ppk is an associated feature of a specific dermatosis. Pdf acquired palmoplantar keratoderma shaily patel. Palmoplantar keratoderma is also sometimes known as keratosis palmaris et plantaris. Dec 15, 2018 acquired palmoplantar keratoderma that may be caused by infections, medications and drugs, or various skin disorders. Acquired keratoderma is a benign skin condition, wherein there is thickening of skin keratoderma of the palms andor soles. Kertatoderma can be inherited, acquired, and rarely, paraneoplastic ie secondary to an internal malignancy. The various forms of ppk can be divided into hereditary forms with only skin problems, hereditary syndromes with ppk. Literature survey and proposed updated classification of the keratodermas. Ppk can also be a feature of various underlying syndromes.
Palmoplantar keratodermas are a diverse group of hereditary and acquired keratodermas in which there is hyperkeratosis of the skin of the palms and soles. Based on the clinical morphology, a distinction is made between diffuseplane, focal patchy, striate, filiform, or discoid or punctate with small, round hyperkeratotic lesions figure 2. Acquired palmoplantar keratoderma may also be due to many causes. Palmoplantar keratoderma an overview sciencedirect topics. Palmoplantar keratosis or palmoplantar keratoderma ppk constitutes a heterogeneous group of disorders characterized by excessive epidermal thickening of the palms and soles of affected individuals 1. Jun 28, 2017 punctate palmoplantar keratoderma type i is a rare condition that affects the skin. Palmoplantar keratoderma ppk or keratosis palmaris et plantaris is part of a group of disorders of the skin affecting primarily the palms of the hands and soles of the feet. Palmoplantar keratoderma is a term used to define a marked thickening of the skin on the palms and soles, either as a focal entity, or diffuse. Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life. The thickening may be symmetrical and found in infants during their first few months of life. Palmoplantar keratodermas can be either genetically inherited or, more often, acquired conditions. Search results palmoplantar keratoderma pubmed health.
Transgredient ppk extends beyond palmoplantar skin, contiguously or as callosities on. Linkage of an american pedigree with palmoplantar keratoderma and malignancy palmoplantar ectodermal dysplasia type iii to 17q24. Related information on causes of palmoplantar keratoderma. Multiple palmoplantar eccrine syringofibroadenomas have also been associated with the syndrome. Sporadic or acquired forms of ppks and genetic or hereditary forms exist. Palmoplantar keratoderma primary care dermatology society uk. Aug 29, 2014 clinical appearance of palmoplantar keratoderma. English iii1 1 department of dermatology, university of. Clinical diagnosis, hereditary palmoplantar keratoderma.
Acquired palmoplantar keratoderma shaily patel,1 matthew zirwas2 and joseph c. Palmoplantar keratoderma may also appear as big masses of kerati. A palmoplantar keratoderma is defined as a persistent thickening of the epidermis of palms and soles, which includes genetic and acquired types. Acquired palmoplantar keratoderma is a multiaetiological disorder and may be the. Dec 29, 2016 palmoplantar keratoderma ppk can be either acquired during the lifetime more commonly or inherited. Conditions listing palmoplantar keratoderma as a symptom may also be potential underlying causes of palmoplantar keratoderma. Palmoplantar keratodermas are a group of disorders characterized by thickening of the skin on the palms of the hands and soles of the feet of affected individuals. Palmoplantar keratodermas ppks consist of a heterogeneous group of disorders characterized by thickening of the palms and soles. Some congenital keratodermas have one or more associated disorders involving bone, muscle, hair, nails, teeth, skin colour, nervous system and the eyes. Palmoplantar keratodermas are a common clinical finding and thus. Palmoplantar keratodermas, also called keratosis palmaris et plantaris or ppks, are a heterogeneous group of disorders marked by an unusual thickening of the skin on the palms of the hands and soles of the feet. Palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles.
In rare forms of ppk, organs other than the skin may also be affected. The topic acquired palmoplantar keratoderma you are seeking is a synonym, or alternative name, or is closely related to the medical condition acquired keratoderma. Palmoplantar keratoderma ppk is a group of skin conditions characterized by thickening of the skin on the palms of the hands and soles of the feet. View the article pdf and any associated supplements and figures for a period of 48 hours. Pdf palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the.
Recognition of the underlying cause is essential for successful treatment. The main types of palmoplantar keratoderma are shown below. Department of dermatology, gifu university graduate school of medicine, gifu, japan. Paraneoplastic palmoplantar keratoderma secondary to. It presents with thickening of the skin of the palms andor soles which may be diffuse involving most of the palms and soles or focal localised mainly to pressure areas. The acquired forms are more common and may reveal a serious.