Multiple palmoplantar eccrine syringofibroadenomas have also been associated with the syndrome. Recognition of the underlying cause is essential for successful treatment. Over 10 million scientific documents at your fingertips. The acquired forms are more common and may reveal a serious. Traditionally they have been classified as either hereditary or acquired and are distinguished from each other on the basis of mode of inheritance, presence of transgrediens defined as contiguous extension of hyperkeratosis beyond the palmar and. Palmoplantar keratodermas foundation for ichthyosis.
Tr eatment of palmoplantar keratoderma with continuous. Clinical diagnosis, hereditary palmoplantar keratoderma. The family of palmoplantar keratodermas are relatively uncommon diseases. Sep 27, 2016 keratoderma climactericum is a type of acquired palmoplantar keratoderma. The diagnosis, treatment, and prognosis of palmoplantar keratoderma. Palmoplantar refers to the skin on the soles of the feet and palms of the hands. Palmoplantar keratodermas can be either genetically inherited or, more often, acquired conditions. Ppk can be either acquired during the lifetime more commonly or inherited. Palmoplantar keratoderma description, causes and risk factors.
Some congenital keratodermas have one or more associated disorders involving bone, muscle, hair, nails, teeth, skin colour, nervous system and the eyes. Palmoplantar keratodermas ppk comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Palmoplantar keratoderma definition of palmoplantar. These forms of ppk may be present in more than one. Palmoplantar keratoderma genetic and rare diseases. The condition may be subdivided into hereditary keratodermas, acquired forms, and conditions in which ppk is an associated feature of a specific dermatosis. The topic acquired palmoplantar keratoderma you are seeking is a synonym, or alternative name, or is closely related to the medical condition acquired keratoderma. Rarer forms of hereditary palmoplantar keratoderma are listed in appendix a.
Differentiation between acquired and hereditary forms is essential for adequate treatment and patient counseling. Inherited forms of ppk are caused by genetic mutations that result in abnormalities of keratin a skin protein. Transgredient ppk extends beyond palmoplantar skin, contiguously or as callosities on. Although very rare, xanthogranulomatous pyelonephritis should be considered in the differential diagnosis of palmoplantar keratoderma. Pdf acquired palmoplantar keratoderma shaily patel. Paraneoplastic skin syndromes melissa piliang, md dermatology and anatomic pathology cleveland clinic. The main types of palmoplantar keratoderma are shown below. It is characterized by thickening of the palms and the soles of individuals who are affected. Pdf palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the. Acquired palmoplantar keratoderma associated with hypothyroidism. Dec 15, 2018 acquired palmoplantar keratoderma that may be caused by infections, medications and drugs, or various skin disorders. Palmoplantar keratoderma medigoo health medical tests and. A palmoplantar keratoderma is defined as a persistent thickening of the epidermis of palms and soles, which includes genetic and acquired types. Palmoplantar keratodermas are a common clinical finding and thus.
Palmoplantar keratoderma is the name given to a group of conditions where there is abnormal thickening of the skin on the palms of the hands and soles of the feet. Punctate palmoplantar keratoderma type i genetic and rare. Acquired palmoplantar keratoderma is more likely to present in adulthood compared with inherited keratodermas which usually present in childhood. Palmoplantar keratodermas ppks comprise of a rare heterogeneous group of genetic and acquired keratinization disorders characterized by hyperkeratotic.
Department of dermatology, gifu university graduate school of medicine, gifu, japan. Acquired palmoplantar keratoderma is a multiaetiological disorder and may be the. Acquired ichthyosis acrokeratosis paraneoplastica extramammary pagets disease pityriasis rotunda florid cutaneous papillomatosis acquired diffuse palmoplantar keratoderma sign of lesertrelat tripe palms. The various forms of ppk can be divided into hereditary forms with only skin problems, hereditary syndromes with ppk as an associated feature, and acquired forms. Acquired palmoplantar keratoderma may also be due to many causes. Palmoplantar keratoderma may also appear as big masses of kerati. After the patients first course of a 5day continuous. Palmoplantar keratoderma is an ailment that involves a rather persistent thickening of the stratum corneum of the palms and soles. Sporadic or acquired forms of ppks and genetic or hereditary forms exist. Ppk can be characterized as either inherited or acquired. Dec 29, 2016 palmoplantar keratoderma ppk can be either acquired during the lifetime more commonly or inherited. His father also had this skin disorder, which coincidentally cleared after 2 courses of chemotherapy consisting of 5fu and cisplatin to treat his lung cancer, prompting the patient to undergo this trial of therapy. Palmoplantar keratoderma genetic and rare diseases information.
Acquired keratoderma is a benign skin condition, wherein there is thickening of skin keratoderma of the palms andor soles. Images in xanthogranulomatous pyelonephritis presenting as. The 3 patients described possess a striking similarity to those with transient reactive papulotranslucent acrokeratoderma. In recent years, speculation has arisen that a molecular genetic classification system will replace the traditional, clinically based, descriptive systems. Acquired palmoplantar keratoderma shaily patel,1 matthew zirwas2 and joseph c.
View the article pdf and any associated supplements and figures for a period of 48 hours. In a large family with epidermolytic palmoplantar keratoderma, reis et al. Related information on causes of palmoplantar keratoderma. Current concepts in diagnosing and treating keratoderma.
Jun 28, 2017 punctate palmoplantar keratoderma type i is a rare condition that affects the skin. Epidermolytic palmoplantar keratoderma vorner type case report. Pdf the ridged skin of the palms and soles has several unique features. Based on the clinical morphology, a distinction is made between diffuseplane, focal patchy, striate, filiform, or discoid or punctate with small, round hyperkeratotic lesions figure 2. Schopfschulzpassarage syndrome is a rare ectodermal dysplasia characterized by hypodontia, hypotrichosis, nail dystrophy, palmoplantar keratoderma, and periocular and eyelid margin hidrocystomas. Palmoplantar keratodermas ppks consist of a heterogeneous group of disorders characterized by thickening of the palms and soles. Our database lists the following as having palmoplantar keratoderma as a symptom of that condition. Gudelines on management of palmoplantar keratoderma. Palmoplantar keratosis or palmoplantar keratoderma ppk constitutes a heterogeneous group of disorders characterized by excessive epidermal thickening of the palms and soles of affected individuals 1.
It is a subtype of punctate palmoplantar keratoderma. Acquired diffuse palmoplantar keratoderma breast lung gastric cancers leukemia lymphomas. Ppk can also be a feature of various underlying syndromes. It may also appear as a snakeskin or have a waxy appearance in infants. Palmoplantar keratodermas are a group of various inherited or acquired afflictions whose common denominator is the thickening of the skin of palms and soles. English iii1 1 department of dermatology, university of. Palmoplantar keratoderma is a thickening of the soles of feet and the palms of the hands. Acquired palmoplantar keratoderma pdf palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Sep 10, 2012 palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. The thickening may be symmetrical and found in infants during their first few months of life. Acquired ppk may arise due to changes in a persons health or environment. How to diagnose and manage hereditary palmoplantar.
Palmoplantar keratoderma primary care dermatology society uk. Paraneoplastic palmoplantar keratoderma ppk is an acquired dermatosis that presents with hyperkeratosis of the palms and soles in association with visceral malignancies eg, esophageal, gastric, pulmonary, and urinarybladder carcinomas. In rare forms of ppk, organs other than the skin may also be affected. Linkage of an american pedigree with palmoplantar keratoderma and malignancy palmoplantar ectodermal dysplasia type iii to 17q24. Palmoplantar keratoderma is classified based on whether it is inherited or acquired and on its clinical features. May 30, 2015 punctate keratoderma this ladys daughter had exactly the same lesions. While palmoplantar keratoderma is in most cases a genetic condition, there are situations in which it can be acquired, usually as a symptom of some inflammatory skin condition, such as psoriasis, eczema, ichthyosis, scabies, or dermatitis. They can also be acquired, such as manifestations of several diseases table. Congenital palmoplantar keratoderma, which is caused by genetic abnormalities that may be inherited in an autosomal dominant or recessive manner. Palmoplantar keratoderma ppk is a group of skin conditions characterized by thickening of the skin on the palms of the hands and soles of the feet. Pdf acquired palmoplantar keratoderma researchgate.
Palmoplantar keratoderma secondary to uterine cancer is rare. Kertatoderma can be inherited, acquired, and rarely, paraneoplastic ie secondary to an internal malignancy. Ppk may be divided into acquired 2 and genetic types 3. Palmoplantar keratodermas ppks are a diverse entity of disorders that are characterized by abnormal thickening of the skin on the palms and soles. Literature survey and proposed updated classification of the keratodermas. Abstract hereditary palmoplantar keratodermas ppks comprise a. Keratoderma is a term that means marked thickening of the skin. Palmoplantar keratodermas are a diverse group of hereditary and acquired keratodermas in which there is hyperkeratosis of the skin of the palms and soles. It presents with thickening of the skin of the palms andor soles which may be diffuse involving most of the palms and soles or focal localised mainly to pressure areas. Diffuse palmoplantar keratoderma is a type of palmoplantar keratoderma that is characterized by an even, thick, symmetric hyperkeratosis over the whole of the palm and sole, usually evident at birth or in the first few months of life. Apr 16, 2019 palmoplantar keratoderma ppk constitutes a heterogeneous group of disorders characterized by thickening of the palms and the soles of individuals who are affected. Aquagenic palmoplantar keratoderma is an acquired condition characterized by burning and edema limited to the hands after brief immersion in water.